Most wouldn't advise using cruise control while towing. You are piloting the vehicle, not the computer - it just controls how much fuel gets dumped in to the motor, when it blows up, and what gear your transmission is in - so when you put it in cruise control, you let the computer try and guess what the road is doing, then react to the varying road conditions. The cruise control on these trucks tries to keep a very tight leash on the speed and not vary a whole lot; my truck only lets the speed drop by maybe 2 MPH before it really gets in to it to push me back up to speed by using more throttle or downshifting. When towing, there's a lot more weight to move around, so the truck is even more aggressive and either dumps more fuel or down shifts (usually the latter), as those are the only two options the computer has to get more power.
IMO, when pulling a trailer, you should be proactive about reading the road and feeding input to the truck via the throttle. Theres a hill coming up? Feed the throttle a little before before you get there to get a little momentum. There's a downhill descent coming up? Let off the throttle, then give the brakes a firm application as you begin to descend (the computer sees this and shifts down a gear or two to help engine brake the vehicle). You slowed down a mile or two an hour because of a small grade in the road? No big deal. Feed it a little more throttle and give it a second to get back up to speed. You're slowing down pretty quickly because of a steep hill? Stab the throttle quickly and the computer reads that as "downshift now!" and it will pop down a gear or two.
What
@Nm6300'asl said is good advice. The "small" downshifts are the converter unlocking which can raise trans temps. Use Tow/Haul mode and/or manually keep it in 5th by shifting to 'S' on the shifter and select '5" (you can shift from D to S while driving without issue, but note that it usually shifts to 4th gear when going from D to S). The RPM's are up a little bit but if you are keeping it around 70-75 MPH they are still fairly low and will prevent a lot of the downshifting.